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Florida Boy Burger Co. Co-Founder Roger Lolly Leads Statewide Expansion with Four New Locations

Rev Up Marketers

Florida Boy Burger Co., the Old-Florida–themed fast-casual concept that has become a local sensation on the Gulf Coast, today announced an ambitious growth plan spearheaded by co-founder and hospitality veteran Roger Lolly. Building on breakout success in Fort Myers and Cape Coral, the company is aiming to open four additional restaurants this year in Orlando, Jacksonville, Naples, and North Port, bringing its signature blend of Florida nostalgia, farm-fresh ingredients, and community-driven hospitality to diners across the state. “Florida Boy Burger was born from our love for the Sunshine State—its history, its wildlife, and, of course, its incredible local produce,” said Roger Lolly, co-founder and head of concept development. “With every new restaurant we open, we get to tell a slice of Florida’s story through design, flavor, and genuine southern hospitality. Expanding north and east lets us share that story with millions more Floridians and visitors alike.” The upcoming locations will mirror the brand’s immersive atmosphere, complete with reclaimed cypress bars, antique postcards, and taxidermy displays that celebrate the Everglades and the Gulf. Each restaurant will feature a 2,800-square-foot dining room, an outdoor patio, and the company’s trademark 500-gallon freshwater tank housing live baby alligators —an educational partnership with the Florida Fish and Wildlife Conservation Commission that teaches conservation while delighting guests. Florida Boy Burger’s scratch menu centers on 100 percent chuck-and-brisket patties, hand-pressed daily and topped with region-inspired flavors such as Key lime aioli, fried plantains, and citrus-maple bacon. A new supply agreement with a cooperative of Panhandle cattle ranchers will enable the chain to introduce fully Florida-raised beef in every market by Q4 2025. Complementing the burger lineup are locally sourced specialties like gator bites, frog legs, and the ever-popular swamp fries smothered in house-made datil-pepper cheese sauce. Co-founder and CFO Louis Cioffi highlighted the economic impact of the rollout: “Each restaurant represents roughly a $1.6 million investment and will create 35 to 40 jobs ranging from line cooks to general managers. We’re also building a centralized training hub in Fort Myers to keep quality high as we scale.” Florida Boy Burger’s momentum has attracted interest from regional developers and franchise investors. While the company remains privately held, Lolly confirmed management is exploring strategic partnerships to accelerate expansion beyond state lines in 2026. “Our near-term focus is Florida,” he said, “but we see a clear runway into neighboring Southeastern markets that appreciate bold flavors and strong storytelling.” Community engagement remains core to the brand’s identity. Through its “Burgers for the Bay” initiative, the company donates a portion of sales each Earth Day to Everglades restoration nonprofits and hosts monthly clean-ups of local waterways. “If we’re celebrating Florida’s beauty, we have to help preserve it,” Lolly added. About Florida Boy Burger Co. Founded in 2022 by restaurateurs Roger Lolly and Louis Cioffi, Florida Boy Burger Co. brings the charm of Old Florida to life through immersive decor, Florida-forward flavors, and a commitment to local sourcing and environmental stewardship. The company operates two locations in Southwest Florida, with four additional openings slated for 2025. Contact Details Florida Boy Roger Lolly roger@burgers.inc Company Website https://burgers.inc/

April 24, 2025 07:17 AM Eastern Daylight Time

TRON Network Surpasses $70 Billion in Circulating USDT

TRON DAO

April 23, 2025 - Geneva, Switzerland - TRON DAO today announced that the total circulating supply of Tether (USDT) on the TRON blockchain has exceeded $70 billion. This achievement reflects growing user demand for cost-efficient, high-speed blockchain-based solutions, particularly in emerging markets and cross-border transactions. TRON has become a preferred settlement layer for stablecoins, driven by its scalability, affordability, and consistent network performance. With more than 302 million accounts, over 10 billion transactions processed, and $20 billion in total value locked (TVL), the TRON network has become a foundational layer for real-world blockchain applications. As of April 2025, TRON facilitates an average of $19 billion in daily USDT transfers, underscoring its capacity to support institutional-scale activity with the efficiency and speed required by the digital economy. In regions facing currency instability and limited access to traditional banking services, TRON’s stability and accessibility have made it an essential financial infrastructure. “USDT on TRON surpassing $70 billion in circulating supply is a powerful reflection of the global community’s trust and support,” said Justin Sun, Founder of TRON. “Behind this figure is a global community that has embraced USDT on TRON as a fast, affordable, and stable means of transacting value. While we see this as a major achievement, it also reinforces our responsibility to continue building secure, scalable, and inclusive financial infrastructure. This progress is the result of collective efforts across the entire crypto ecosystem, and we remain committed to advancing real-world utility through stablecoin innovation.” As part of its broader commitment to responsible innovation, TRON—together with Tether and TRM Labs—established the T3 Financial Crime Unit (T3 FCU) to combat illicit activities on the blockchain. Since its inception, T3 FCU has assisted in freezing over $150 million in collaboration with law enforcement agencies worldwide, demonstrating that decentralized networks can support financial integrity at scale while maintaining transparency and compliance. With over $70 billion USDT circulating on the network, TRON plays a central role in the stablecoin economy by offering a fast, low-cost, and scalable platform for global digital asset transfers. Its growth reflects a continued focus on expanding financial access, enhancing interoperability, and working collaboratively with key players across various verticals to build a secure and inclusive blockchain infrastructure. About TRON DAO TRON DAO is a community-governed DAO dedicated to accelerating the decentralization of the internet via blockchain technology and dApps. Founded in September 2017 by H.E. Justin Sun, the TRON blockchain has experienced significant growth since its MainNet launch in May 2018. Until recently, TRON hosted the largest circulating supply of USD Tether (USDT) stablecoin, exceeding $70 billion. As of April 2025, the TRON blockchain has recorded over 302 million in total user accounts, more than 10 billion in total transactions, and over $20 billion in total value locked (TVL), based on TRONSCAN. TRONNetwork | TRONDAO | X | YouTube | Telegram | Discord | Reddit | GitHub | Medium | Forum Media Contact Yeweon Park press@tron.network Contact Details Yeweon Park press@tron.network Company Website https://trondao.org/

April 23, 2025 07:03 PM Eastern Daylight Time

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PEOPLES FINANCIAL CORPORATION REPORTS RESULTS FOR THE FIRST QUARTER OF 2025

Peoples Financial Corporation

Peoples Financial Corporation (the “Company”)(OTCQX Best Market: PFBX), parent of The Peoples Bank (the “Bank”), announced earnings for the first quarter ending March 31, 2025. First Quarter Earnings Net income for the first quarter of 2025 decreased $1,105,000 to $1,310,000 compared to net income of $2,415,000 for the first quarter of 2024. The earnings per weighted average common share for the first quarter of 2025 were $0.28 compared to earnings per weighted average common share of $0.52 for the first quarter of 2024. Per share figures are based on weighted average common shares outstanding of 4,617,466 and 4,661,686 for the first quarters of 2025 and 2024, respectively. The decrease in net income for the first quarter of 2025 was primarily due to a decrease in net interest income of $1,025,000 to $5,668,000 for the first quarter of 2025 compared with $6,693,000 for the first quarter of 2024. Total interest income decreased by $1,370,000 to $7,559,000 for the first quarter of 2025 as compared with $8,929,000 for the first quarter of 2024 due to lower interest income on securities caused by a decrease in balances and yields. Total interest expense decreased by $345,000 to $1,891,000 for the first quarter of 2025 as compared with $2,236,000 for the first quarter of 2024 due to lower interest rates paid on deposit accounts and lower borrowing costs. Return on average assets for the first quarter ended March 31, 2025, decreased 0.50% to 0.62% compared to 1.12% for the first quarter ended March 31, 2024. The Company’s efficiency ratio increased 13% to 77% for the first quarter ended March 31, 2025, compared to 64% for the first quarter ended March 31, 2024. Asset Quality “The Bank’s leadership remains committed to maintaining high-quality assets. We are closely monitoring economic conditions and staying vigilant for any potential changes in interest rates,” said Chevis C. Swetman, chairman and chief executive officer of the Company and the Bank. Shareholders’ Equity Total shareholders’ equity increased by $4,454,000 from $90,001,000 at December 31, 2024, to $94,455,000 at March 31, 2025. The improvement in shareholders’ equity was mainly due to quarterly earnings of $1,310,000 through March 31, 2025. The Company also experienced a decrease of $3,144,000 in unrealized losses on securities in 2025. The Company reported $34,862,000 and $38,006,000 in unrealized losses on the available for sale securities portfolio as of March 31, 2025, and December 31, 2024, respectively. These unrealized losses are presented in accumulated other comprehensive income for the respective periods. The cause of the unrealized losses has primarily resulted from higher interest rates that have impacted the current market value of available for sale securities. The unrealized losses are not related to any credit deterioration within the portfolio. The Company has maintained strong liquidity and continues to do so; therefore, the Company does not foresee a sale of any affected securities that would cause the realization of these losses by the Company as part of net income in the near future. The Bank’s leverage ratio has not been impacted by these unrealized losses on available for sale securities due to an optout election previously made by the Bank in accordance with current regulatory capital requirements and therefore remained strong at 13.32% as of March 31, 2025. Liquidity The Company maintains a well-capitalized balance sheet which includes strong capital and liquidity. The Bank provides a full range of banking, financial and trust services in our local markets. The majority of the Bank’s deposits are fully FDIC insured. The Company evaluates on an ongoing and continuous basis its financial health by preparing for various moderate to severe economic scenarios. As interest rates have increased and the cost of attracting new deposits and replacing deposit attrition has increased, the Bank experienced an increase in its cost of funds during the twelve months ended December 31, 2024. As of March 31, 2025 total deposits have increased $31,261,000 to $751,991,000 from $720,730,000 as of December 31, 2024. This is mainly due to an influx of public fund tax deposits during the first and last quarters of 2025 and 2024 that were slowly allocated by the public accountholders throughout the year. About the Company Founded in 1896, with $867 million in total assets as of March 31, 2025, The Peoples Bank operates 18 bank facilities along the Mississippi Gulf Coast in Hancock, Harrison, Jackson and Stone counties. In addition to offering a comprehensive range of retail and commercial banking services, the Bank also operates a trust and investment services department that has provided customers with financial, estate and retirement planning services since 1936. Peoples Financial Corporation’s common stock is listed on the OTCQX Best Market under the symbol PFBX. Additional information is available on the Internet at the Company’s website, www.thepeoples.com, and at the website of the Securities and Exchange Commission (“SEC”), www.sec.gov. This news release reflects industry conditions, Company performance and financial results and contains “forward-looking statements,” which may include forecasts of our financial results and condition, expectations for our operations and businesses, and our assumptions for those forecasts and expectations. Do not place undue reliance on forward-looking statements. These forward-looking statements are subject to a number of risk factors and uncertainties which could cause the Company’s actual results and experience to differ materially from the anticipated results and expectation expressed in such forward-looking statements. Factors that could cause our actual results to differ materially from our forward-looking statements are described under “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and “Regulation and Supervision” in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2024, and in other documents subsequently filed by the Company with the Securities and Exchange Commission, available at the SEC’s website and the Company’s website, each of which are referenced above. To the extent that statements in this news release relate to future plans, objectives, financial results or performance by the Company, these statements are deemed to be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statementsare generally identified by use of words such as “may,” “believe,” “expect,” “anticipate,” “intend,” “will,” “should,” “plan,” " “estimate,” “predict,” “continue” and “potential” or the negative of these terms or other comparable terminology. Forward-looking statements represent management’s beliefs, based upon information available at the time the statements are made, with regard to the matters addressed; they are not guarantees of future performance. Forward-looking statementsare subject to numerous assumptions, risks and uncertainties that change over time and could cause actual results or financial condition to differ materially from those expressed in or implied by such statements. All information is as of the date of this news release. Except to the extent required by applicable law or regulation, the Company undertakes no obligation to revise or update publicly any forward-looking statement for any reason. Contact Details Peoples Financial Corp Chevis C. Swetman, President and CEO +1 228-435-8205 cswetman@thepeoples.com Company Website https://www.thepeoples.com

April 23, 2025 03:05 PM Central Daylight Time

News Release

Van Ness Corridor Emerges as San Francisco’s Premier Medical Destination

The Hoyt Organization

The Van Ness corridor has become one of San Francisco’s most dynamic medical and healthcare destination, anchored by the world-class Sutter Health’s California Pacific Medical Center and supported by an expanding ecosystem of medical office spaces and care providers. A highlight of this transformation is the 45,000 square feet of premium medical office space currently available at 939 Ellis St., making it the largest contiguous medical space on the market in San Francisco today. Strategically located just steps away from Sutter’s Van Ness campus, 939 Ellis offers an unparalleled opportunity for medical groups, specialty clinics, and healthcare innovators looking to establish a presence in the city’s fastest-growing healthcare hub. Ellis’ central location provides convenience for patients commuting from East Bay, the Peninsula, and Marin County. Connectivity to the Van Ness Corridor has never been better with the 2022 launch of the Van Ness Bus Rapid Transit, a 1.96-mile route running north-south featuring dedicated center bus lanes and nine stations. “The synergy between the neighborhood’s thriving healthcare community and access to transportation is reshaping the Van Ness corridor into a one-stop destination for high-quality patient care,” said Kurt Hackett, Vice President of Asset Management with Rethink Healthcare Real Estate, a private investment group that owns 939 Ellis St. “Whether it’s primary care, outpatient specialties, diagnostics, or wellness services, everything patients and providers need is increasingly concentrated in this central, transit oriented neighborhood.” The building, which is already about half occupied by Kaiser Permanente, comes to market amid a notable resurgence in San Francisco’s economy as the city positions itself for a boom in AI investments. The increase in business is being further fueled by the return-to-office trend and a growing belief that San Francisco is on the right track, according to recent surveys. Recently elected Mayor Daniel Lurie has spearheaded many new efforts that are working to bring businesses and visitors back to the world class downtown. As demand for centrally located, modern medical space continues to rise, the Van Ness corridor stands out as a focus for San Francisco’s healthcare future. “We could not be more bullish on this location,” said Jonathan Winer, President of Rethink Healthcare Real Estate. “Not only is San Francisco’s reemergence as a hotbed of business activity a catalyst for those looking to treat patients locally, but the ease of transit has made the Van Ness Corridor a convenient destination for doctors and patients, alike, who are coming from the outskirts of the city or the suburbs.” 939 Ellis St. offers flexible, build-ready medical office suites that can accommodate a range of specialties. It boasts a scenic rooftop terrace and available parking. For leasing inquiries at 939 Ellis St., contact Trask Leonard, president and CEO of Bayside Realty Partners at tleonard@baysiderp.com or Caroline Doyle, senior vice president of Bayside Realty Partners, at cdoyle@baysiderp.com. Contact Details The Hoyt Organization Andrew King +1 914-513-6895 aking@hoytorg.com Company Website https://rethink-capital.com/healthcare-real-estate/

April 23, 2025 10:20 AM Pacific Daylight Time

BridgeFT and iCapital® Launch New Portfolio Data Management Solution for Wealth Managers

BridgeFT

BridgeFT, a cloud-native, API-first wealth infrastructure software company, and iCapital [1], the global fintech platform driving the world’s alternative investment marketplace for the wealth and asset management industries, announced today a first-of-its-kind partnership to deliver a comprehensive data solution across all asset classes for the wealth management industry, including RIAs, wealth management firms and TAMPs. As financial advisors navigate increasingly complex and diversified portfolios across a wide spectrum of public securities, private market investments, structured investments and annuities, and direct, off-platform investments—accessing, standardizing, and analyzing comprehensive data has become a significant challenge. This partnership directly addresses that challenge with a unified, scalable, and intelligent solution designed to empower advisors by providing a complete view of client portfolios across asset classes and spanning thousands of positions on and off iCapital’s platform. “Increased appetite for alternative investments is driving demand for a comprehensive view of client investments. iCapital is at the forefront of creating a standardized industry framework that optimizes the entire alternative investing experience, and we are thrilled to be partnering with the iCapital team on this data initiative,” said Dave Hagen, BridgeFT’s Chief Commercial Officer. “Our work together emphasizes our commitment to being a true technology enabler for advisors, making it easier for them to gain access to critical total wealth data to further enable differentiation and accelerate growth.” iCapital’s Alternative Data Management service leverages machine learning and AI to provide timely and accurate data retrieval, transformation, validation, and delivery to any downstream reporting system. Combined with BridgeFT’s ability to consolidate custodial and transactional data across public market platforms, the new solution is designed to give advisors unprecedented insight into portfolio performance, risk, liquidity, and allocation strategy. “Our partnership with BridgeFT reflects our commitment to providing innovative data solutions and an enhanced advisor and client experience,” said Dan Vene, Co-Founder and Co-Head of iCapital Solutions. “By continually evolving our data solutions, we strive to enable advisors to work more efficiently, access real-time data, make smarter decisions, and deliver superior service with a focus on what truly matters – guiding clients toward their financial goals with confidence and clarity.” iCapital is the latest partner to be added to BridgeFT's WealthTech API Marketplace, which offers the wealth market direct access to a curated group of partners reshaping wealth management technology with API-first data and application services that are pre-integrated with BridgeFT’s WealthTech API infrastructure. BridgeFT’s Marketplace aims to accelerate, simplify, and reduce the cost of wealth management application development and maintenance. [1] iCapital, Inc. and its affiliates (together, “iCapital”) About BridgeFT BridgeFT is a cloud-native, API-first wealth infrastructure software company that enables financial institutions, FinTech innovators, TAMPs, and registered investment advisors to deliver better, data-driven outcomes for their clients. Our WealthTech-as-a-Service platform, WealthTech API, makes wealth management technology better by accelerating, simplifying and reducing the cost of app development and maintenance, so our clients can focus on delivering next generation wealth management applications and unique digital experiences that amplify their differentiators. Leading financial services firms and technology companies trust BridgeFT to power their digital wealth management ecosystems and automate critical back-office operations seamlessly aligning multi-custodial data aggregation, advanced analytics and reporting, and application services to deliver truly personalized client experiences. For more information, visit bridgeft.com. Contact Details For BridgeFT Lisa Aldape, Vocatus laldape@vocatusllc.com Company Website https://www.bridgeft.com/

April 23, 2025 10:00 AM Eastern Daylight Time

AdvicePay Releases Third Annual Trend Report, Revealing Growth in Subscription-Based Financial Planning

AdvicePay

AdvicePay, the industry-leading platform for managing billing, payments, and compliance of fee-for-service financial planning, released its third annual Fee-for-Service Industry Trend Report. The findings, based on over 461,000 transactions processed in 2024, highlight a growing trend in subscription-based models – an increasingly popular choice for advisors seeking stable and predictable revenue streams amid volatile markets. The report reveals that subscription-based models continue to dominate the fee-for-service landscape. In 2024, a substantial 85% of all invoices were subscription-based, up from 83% the previous year. This shift marks a continued rise in the popularity of monthly and quarterly subscriptions, as well as a notable increase in the fees charged for these services. Specifically, advisors raised their average monthly subscription fees to $278, up 4.9% from $265 in 2023, while quarterly subscriptions saw a 1.4% increase, and one-time fees grew by 2.9%. The trend toward higher subscription fees and a preference for digital payments also reflects broader changes in client behavior. In 2024, over half (53.4%) of all transactions were completed using credit or debit cards, while 45.9% were processed through ACH transfers. These findings underscore the growing adoption of subscription-based models across the industry. Despite common misconceptions, the report highlights that fee-for-service planning is not replacing assets under management (AUM) fees, but rather providing a complementary revenue stream. In times of market volatility, fee-for-service financial planning offers advisors a more stable and predictable income, akin to a "bond" in an advisor’s income portfolio. As AUM fees fluctuate with market conditions, advisors are leveraging fee-for-service models to reach new, underserved demographics and secure steady cash flow. “Adoption of the fee-for-service model is no longer a niche trend, it’s a strategic necessity for broker-dealers and RIAs aiming to remain resilient and competitive in recruitment and retention of both advisors and clients,” said Alan Moore, Co-Founder and CEO of AdvicePay. “The sustained growth across key metrics signals that subscription-based planning is becoming a core part of financial advisory firms’ revenue strategies. It allows firms to expand their client base, offer flexible pricing, and mitigate the risk of market volatility.” The increasing popularity of fee-for-service planning is further evidenced by the growth in transactions on the AdvicePay platform, which processed 461,000 transactions in 2024, up from 380,000 the previous year. Since its public launch in 2018, AdvicePay has processed over $838 million in financial planning fees, firmly establishing fee-for-service financial planning as a mainstream and essential business model. Released just last week, the 2025 Trend Report already has over 400 downloads to date. To receive a copy of the full report, which includes analysis of over two million data points, please visit https://info.advicepay.com/trends. About AdvicePay AdvicePay is the industry-leading platform for overseeing the compliance, delivery, and payment processing of fee-for-service financial planning. Financial services firms and their advisors benefit from efficient workflows designed exclusively to support their fee-for-service financial planning revenue, including up-to-date compliance and data security management, all in one unified platform. Contact Details Shannon Beck +1 406-412-2047 media@advicepay.com Company Website https://advicepay.com/

April 23, 2025 10:00 AM Eastern Daylight Time

NAFA Announces Lineup for 2025 Indoor EV Test Track and Ride & Drive Experience at I&E

NAFA Fleet Management Association

NAFA Fleet Management Association (NAFA) is excited to announce the lineup for two cutting-edge events at the 2025 Institute & Expo (I&E) that will highlight the latest advancements in fleet technology: the Indoor EV Test Track and the Ride & Drive Experience. These events, powered by Automotive Fleet, will provide attendees with unique opportunities to experience electric and alternative fuel vehicles, both in the passenger seat and behind the wheel. “The Indoor EV Test Track and Ride & Drive Experience are essential opportunities for fleet professionals to experience firsthand the cutting-edge technologies and innovations shaping the future of fleet management,” said Bill Schankel, CAE, CEO of NAFA. “Both events showcase the rapid advancement of the electric vehicle and alternative fuel industries, and we’re excited to bring these dynamic experiences to I&E 2025.” Indoor EV Test Track: A Ride-Along Experience with the Latest Electric Vehicles Tuesday, April 29: 10:00 a.m. – 2:00 p.m. Wednesday, April 30: 10:00 a.m. – 1:30 p.m. The Indoor EV Test Track invites attendees to step into the passenger seat for an exclusive ride-along experience featuring the newest electric vehicles in the industry. This event provides a rare opportunity to experience the performance and technology of EVs on an indoor track located in the Expo Hall. Participating manufacturers include: Ford Lucid Nissan PoleStar Rivian Volkswagen Volvo Inspiration Fleet, sponsor of the Indoor EV Test Track, will provide a viewing lounge near the check-in area. Outdoor Ride & Drive Experience: Get Behind the Wheel of the Latest Fleet Vehicles Wednesday, April 30: 3:00-5:00 p.m. The Ride & Drive Experience gives attendees the chance to get behind the wheel of some of the most innovative electric and alternative fuel vehicles on the market. Participants can drive vehicles from top manufacturers, including: Ford Lucid Mercedes Benz Nissan PoleStar Ram Professional Rivian Toyota UPower Volkswagen Volvo These are just two of the many exciting elements of I&E 2025, which will feature over 40 educational sessions, hands-on demonstrations and networking opportunities. This year’s sponsors include Automotive Fleet, Enterprise Fleet Management, FASTER Asset Solutions, Fleetio, Fleetworthy, Geotab, Holman, Honda, Hyundai Motor America, Inspiration Fleet, IntelliShift, LEGEND, Merchants Fleet, Mitsubishi Motor Sales of Canada, Motive, Penske Transportation Solutions, Ram Professional, Reindeer Logistics, LLC, Rexel Energy, RTA The Fleet Success Company, Samsara, Voyager Mastercard, and Wheels, Inc. NAFA Fleet Management Association is the membership organization for professionals who manage the mobility requirements of vehicle fleets that include commercial, public safety, trucks, and buses of all types and sizes, and a wide range of military and off-road equipment for corporations, governments, universities, utility fleets, and law enforcement in North America and across the globe. NAFA’s members are responsible for the specification, acquisition, maintenance, repair, fueling, risk management, and remarketing of more than 4.8 million vehicles that drive an estimated 84 billion miles each year. NAFA’s members control assets and services well above $122 billion each year. For more information, please visit www.nafa.org, and communicate with NAFA on LinkedIn, Facebook, and X. Contact Details Keaveny Hewitt +1 919-622-5276 khewitt@onwrdupwrd.com Company Website https://www.nafa.org/

April 23, 2025 10:00 AM Eastern Daylight Time

Silexion Therapeutics Collaborates with Multi Billion Dollar Clinical Development Player, Advancing Revolutionary Cancer Treatment Toward Clinical Trials

Global Markets News

Silexion Therapeutics' (NASDAQ: SLXN) * groundbreaking RNAi therapy showing 70-80% tumor reduction takes major step forward with global manufacturing collaboration; Wall Street analysts reportedly maintain $5 price target representing potential 500% upside as company targets $470B precision medicine market Game-Changing Partnership Announcement In a strategic move that significantly advances its revolutionary cancer treatment pipeline, Silexion Therapeutics (NASDAQ: SLXN) announced today a collaboration with global therapeutics giant Catalent to optimize and manufacture its breakthrough KRAS-targeting therapy SIL204. This partnership represents a critical acceleration toward human clinical trials, expected to begin in the first half of 2026. The collaboration will leverage Catalent's state-of-the-art Limoges, France facility—a European center of excellence for complex biologics formulation—to optimize both systemic and intratumoral delivery formulations of SIL204, supporting Silexion's innovative dual-route strategy targeting both primary tumors and metastases. "Our collaboration with Catalent represents a significant advancement in our SIL204 development program," said Ilan Hadar, Chairman and CEO of Silexion Therapeutics. "Catalent's expertise in complex formulation development will be instrumental as we work toward our goal of initiating human clinical trials in the first half of 2026." Disrupting the "Undruggable": Silexion's Breakthrough Approach to KRAS Mutations Silexion's technology stands at the frontier of precision oncology, targeting KRAS mutations—long considered the "holy grail" of cancer targets and present in over 90% of pancreatic cancers. While competitors have developed small molecule inhibitors that target only specific KRAS mutations (primarily G12C, found in just 1-2% of pancreatic cancers), Silexion's RNA interference approach silences multiple KRAS mutations at the genetic level. Recent preclinical data revealed SIL204's remarkable efficacy across multiple pancreatic cancer models: 70% reduction in tumor burden in AsPC-1 models (KRAS G12D mutation) Significant dose-dependent tumor reduction in Panc-1 models (KRAS G12D mutation) 80% tumor reduction in BxPC-3 models Most critically, for the first time, Silexion demonstrated SIL204's ability to reduce metastatic spread to secondary organs—a game-changing advancement that could transform treatment paradigms for aggressive pancreatic cancer. Dual-Route Strategy: A Comprehensive Attack on Cancer Silexion recently unveiled its expanded development plan for SIL204, integrating both systemic administration for targeting metastatic progression and intratumoral delivery for attacking primary tumors—a comprehensive approach unique in KRAS-targeted therapies. The orthotopic models used in Silexion's breakthrough studies better represent human pancreatic cancer biology by allowing tumors to develop in their native environment. This stands in contrast to subcutaneous xenograft models, where tumors grow beneath the skin rather than in the organ of origin. This expanded approach is supported by SIL204's demonstrated ability to maintain therapeutic levels for over 56 days from a single administration—an unprecedented achievement in RNAi therapeutics. Massive Market Opportunity in Precision Oncology The partnership with Catalent positions Silexion advantageously within the rapidly growing precision medicine market, projected to surge from $102 billion in 2024 to $470 billion by 2034, growing at a CAGR of 16.5%. Within this broader market, KRAS-driven cancers represent a substantial unmet need, with the market for KRAS inhibitors expected to grow at an impressive 36% CAGR, reaching $10 billion by 2032. Recent years have seen unprecedented consolidation in precision oncology, with big pharma aggressively seeking innovative assets: Pfizer's landmark $43 billion acquisition of Seagen in 2023 AbbVie's $10.1 billion purchase of Immunogen Numerous other multi-billion dollar transactions for targeted oncology assets With major pharmaceutical companies collectively holding over $170 billion in cash reserves, according to reports, the M&A environment remains highly favorable for innovative companies developing breakthrough cancer therapeutics. Wall Street's Bullish Outlook: Over 500% Potential Upside Wall Street analysts appear to recognize Silexion's potential, with Maxim Group maintaining a Buy rating and a $5 price target—representing a remarkable premium of over ~500% from today's pre market price. This seemingly bullish stance reflects confidence in Silexion's differentiated technology, promising preclinical data, and clear strategic roadmap. Silexion's partnership with Catalent adds credibility to its development roadmap, which includes toxicology and pharmacodynamic studies throughout 2025, regulatory submissions to the Israel Ministry of Health in H2 2025 and the European Union in H1 2026, and the initiation of human clinical trials in 2026. A Potential Industry Game-Changer to Watch Silexion Therapeutics stands at a pivotal moment in its development journey. With groundbreaking preclinical data demonstrating efficacy against both primary tumors and metastases, a clear strategic roadmap to clinical trials, and now a global manufacturing partnership with Catalent, the company is positioned at the intersection of high unmet medical need and significant market opportunity. As pancreatic cancer remains one of the deadliest malignancies with a dismal five-year survival rate below 13%, Silexion's innovative approach targeting multiple KRAS mutations could represent a transformative advancement in treatment paradigms—potentially reshaping the landscape for one of oncology's most challenging diseases. For investors seeking exposure to next-generation precision oncology, Silexion represents a unique opportunity to participate in the development of a potentially disruptive technology addressing one of medicine's most significant challenges. News Highlights from Silexion: - Silexion Therapeutics Announces Collaboration with Global Therapeutics Leader Catalent on Advanced siRNA Formulation Development & Clinical Manufacturing Activities - Silexion Therapeutics Unveils Innovative Expanded Development Plan for SIL204 Based on Recent Groundbreaking Preclinical Data - Silexion Therapeutics Reports Groundbreaking Positive Initial Data from Systemic Administration of SIL204 in Orthotopic Pancreatic Cancer Models *Disclaimer: This article was written and published by Wall Street Wire™, a promotional content and distribution brand and network. Nothing in this article constitutes financial or investment advice, nor does it represent an offer to buy or sell securities. The operators of Wall Street Wire network are not registered brokers, dealers, or investment advisers. This article contains and is a form of paid promotional content related to Silexion Therapeutics and was produced as part of their paid subscription to Wall Street Wire. This article has not been reviewed or approved by Silexion Therapeutics prior to publication. The information in this article is based on publicly available news reports and filings which have not been independently verified by us. Please review the full disclaimers and compensation disclosures here: redditwire.com/terms. Contact Details Wall Street Wire | Coverage Desk media.globalmarkets@gmail.com

April 23, 2025 09:54 AM Eastern Daylight Time

Direxion Adds Boeing & Exxon Mobil to Single Stock Daily Leveraged & Inverse ETF Lineup

Direxion

Direxion, a leading provider of ETFs for tactical traders, and a pioneer in Single Stock Daily Leveraged & Inverse ETFs, expanded its suite of high-powered trading tools with the launch of four new funds tracking the performance of The Boeing Company (BA) and Exxon Mobil Corporation (XOM). These funds provide traders with amplified, or inverse, exposure to BA or XOM via the Direxion Daily BA Bull 2X Shares (Ticker: BOEU) and Direxion Daily BA Bear 1X Shares (Ticker: BOED), or the Direxion Daily XOM Bull 2X Shares (Ticker: XOMX) and Direxion Daily XOM Bear 1X Shares (Ticker: XOMZ). “Active traders thrive on the catalysts these two headline-heavy stocks provide, to include recent tariff-related news,” said Douglas Yones, CEO of Direxion. “For Boeing, it may be regulatory announcements, airline orders and production issues, while for Exxon it could be crude oil prices, associated demand fluidity and geopolitical moves. These ETF pairs provide the focused exposure active traders seek to express their short-term convictions on both." Designed for active traders, Direxion’s pairs of Single Stock Leveraged & Inverse ETFs are built for short-term trading − not long-term investing. These ground-breaking trading tools are intended for experienced traders with a high risk tolerance. Unlike traditional ETFs, or even other leveraged and/or inverse ETFs, these products track the price of a single stock rather than an index, offering no diversification benefits. All Direxion leveraged and inverse ETFs are intended only for investors with an in-depth understanding of the risks associated with seeking leveraged investment results, and who plan to actively monitor and manage their positions. There is no guarantee these ETFs will meet their objective. Please visit the Direxion Leveraged and Inverse ETF Education Center, where you will find educational brochures, videos, and a self-paced online course to help you understand if leveraged and inverse ETFs – including single stock ETFs – are right for you. About Direxion: Direxion equips investors who are driven by conviction with ETF solutions built for purpose and fine-tuned for precision. These solutions are available for a broad spectrum of investors, whether executing short-term tactical trades, or investing in thematic strategies. Direxion’s reputation is founded on developing products that precisely express market perspectives and allow investors to manage their risk exposure. Founded in 1997, the company has approximately $40.7 billion in assets under management as of March 31, 2025. For more information, please visit www.direxion.com. There is no guarantee that the Funds will achieve their investment objectives. For more information on all Direxion Shares ETFs, go to www.direxion.com, or call us at 866.301.9214. An investor should carefully consider a Fund’s investment objective, risks, charges, and expenses before investing. A Fund’s prospectus and summary prospectus contain this and other information about the Direxion Shares. To obtain a prospectus and summary prospectus call 866.476.7523 or visit our website at direxion.com. A Fund’s prospectus and summary prospectus should be read carefully before investing. Investing in the funds involves a high degree of risk. Unlike traditional ETFs, or even other leveraged and/or inverse ETFs, these leveraged and/or inverse single-stock ETFs track the price of a single stock rather than an index, eliminating the benefits of diversification. Leveraged and inverse ETFs pursue daily leveraged investment objectives, which means they are riskier than alternatives which do not use leverage. They seek daily goals and should not be expected to track the underlying stock’s performance over periods longer than one day. They are not suitable for all investors and should be utilized only by investors who understand leverage risk and who actively manage their investments. The Funds will lose money if the underlying stock’s performance is flat, and it is possible that the Bull Fund will lose money even if the underlying stock’s performance increases, and the Bear Fund will lose money even if the underlying stock’s performance decreases, over a period longer than a single day. Investing in the Funds is not equivalent to investing directly in BA or XOM. Direxion Shares Risks – An investment in a Fund involves risk, including the possible loss of principal. Each Fund is non-diversified and includes risks associated with a Fund concentrating its investments in a particular security, industry, sector, or geographic region which can result in increased volatility. A Fund's investments in derivatives such as futures contracts and swaps may pose risks in addition to, and greater than, those associated with directly investing in securities or other investments, including imperfect correlations with underlying investments or the Fund's other portfolio holdings, higher price volatility and lack of availability. As a result, the value of an investment in a Fund may change quickly and without warning. Leverage Risk – The Bull Fund obtains investment exposure in excess of its net assets by utilizing leverage and may lose more money in market conditions that are adverse to its investment objective than a fund that does not utilize leverage. A total loss may occur in a single day. Leverage will also have the effect of magnifying any differences in the Fund’s correlation with BA or XOM and may increase the volatility of the Bull Fund. Daily Correlation Risk - A number of factors may affect the Bull Fund’s ability to achieve a high degree of correlation with BA or XOM and therefore achieve its daily leveraged investment objective. The Bull Fund’s exposure to BA or XOM is impacted by BA or XOM’s movement. Because of this, it is unlikely that the Bull Fund will be perfectly exposed to BA or XOM at the end of each day. The possibility of the Bull Fund being materially over- or under-exposed to BA or XOM increases on days when BA or XOM is volatile near the close of the trading day. Daily Inverse Correlation Risk - A number of factors may affect the Bear Fund’s ability to achieve a high degree of inverse correlation with BA or XOM and therefore achieve its daily inverse investment objective. The Bear Fund’s exposure to BA or XOM is impacted by BA or XOM’s movement. Because of this, it is unlikely that the Bear Fund will be perfectly exposed to BA or XOM at the end of each day. The possibility of the Bear Fund being materially over- or under-exposed to BA or XOM increases on days when BA or XOM is volatile near the close of the trading day. The Boeing Company Investing Risk - Issuer-specific attributes may cause an investment held by the Fund to be more volatile than the market generally. The Boeing Company faces risks associated with commercial airlines, including demand for commercial aircraft and related services and commercial airlines sales contract terms; adverse government regulations; regulatory compliance costs; supply chain and manufacturing disruptions; litigation and government inquires and investigations; changes in U.S. government defense spending or priorities; among other risks. Aerospace and Defense Industry Risk - The aerospace and defense industry can be significantly affected by government regulation and spending policies because companies involved in this industry rely, to a significant extent, on government demand for their products and services. Industrials Sector Risk - Stock prices of issuers in the industrials sector are affected by supply and demand both for their specific product or service and for industrials sector products in general. Exxon Mobil Corporation Investing Risk – Issuer-specific attributes may cause an investment held by the Fund to be more volatile than the market generally. Exxon Mobil Corporation faces risks associated with supply and demand of commodities, political instability and the potential for significant changes in the regulatory environment; general economic conditions and the related impact on demand; ability to maintain and grow production of oil and gas products; the inherent risks and hazards associated with the crude oil and natural gas industries; among other risks. Oil and Gas Industry Risk - Companies in the oil and gas industries are affected by supply and demand both for their specific product or services and for energy products in general. Energy Sector Risk - Energy sector securities may be adversely impacted by changes in the levels and volatility of global energy prices, global supply and demand, and capital expenditures on the exploration and production of energy sources. Additional risks of each Fund include Effects of Compounding and Market Volatility Risk, Derivatives Risk, Counterparty Risk, Rebalancing Risk, Intra-Day Investment Risk, Industry Concentration Risk, Market Risk, Indirect Investment Risk, and Cash Transaction Risk. Additionally, for the Direxion Daily BA Bear 1X Shares and Direxion Daily XOM Bear 1X Shares, Shorting or Inverse Risk. Please see the summary and full prospectuses for a more complete description of these and other risks of a Fund. Distributor: ALPS Distributors, Inc. Contact Details Danielle Black, AD direxion@dittopr.co Company Website https://www.direxion.com/

April 23, 2025 09:00 AM Eastern Daylight Time

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